Electron microscopic and cytochemic findings in Di-Guglielmo's syndrome and in other forms of leukemia.

ELECTRON MICROSCOPIC AND CYTOCHEMIC FINDINGS IN Di-GUG,LIELMO'S SYNDROME AND IN OTHER FORMS OF LEUKEMIA

The leukemic cell shows many peculiarities in contrast to normal ones. In particular, these are not specific for leukemia; by their quantity and combination they irnprove classification and understanding of this disease. In order to avoid an exhaustive list of morphologic findings, a certain order of our results we shall try to achieve. In doing this we accept the risk of possibly oversimplifyi...

Prolonged remission in Di Guglielmo's syndrome.

A case is reported of a 12-year-old boy with Di Guglielmo's syndrome who achieved complete remission for over three years before developing a central nervous system relapse. The poor results of treatment in this disease are reviewed and the arguments for routine central nervous system prophylaxis discussed.

The natural history of trilinear myelodysplastic syndrome and erythroleukemia.

A case of Di Guglielmo's syndrome passed through the three stages of chronic erythromyelosis, erythroleukemia and acute myeloid leukemia (AML). According to the FAB classification the subsequent stages of this syndrome were refractory anemia (RA), RA with excess of blasts (RAEB), AML-M6, AML-M2 and undifferentiated AML-MO as the end-stage disease. Light- and electronmicroscopice findings on per...

Di Guglielmo's syndrome with low serum vitamin B12.

Autonomous erythropoiesis during erythroblastic crisis of chronic myelocytic leukemia.

Two patients with chronic myelocytic leukemia who developed an erythroblastic rather than a myeloblastic phase were studied with respect to whether or not the megaloblastic erythropoiesis was subject to normal control mechanisms. After transfusion, no significant reduction was observed in the percentage of nucleated erythroid precursors or of proerythroblasts in marrow or in blood reticulocytes...